Table 3 Results of functional and structural brain features

(A) Between-group difference in seed-based connectivity

cluster size (voxel)

clusterp_{FWE−corrected}

MNI coordinates

Z

Region

x

y

z

Seed: Left SMN

D > ND

545

< 0.001

32

4

46

4.5

R

Middle frontal gyrus

36

4

30

4.3

R

Primary motor cortex

30

6

54

3.9

R

Middle frontal gyrus

ND > D

192

0.009

-32

-18

14

4.0

L

Posterior insula

-38

-28

22

4.0

L

-34

-12

22

3.8

L

Seed: Right SMN

D > ND

213

0.006

28

4

40

4.6

R

Middle frontal gyrus

34

8

46

4.2

34

0

68

4.0

R

Superior frontal gyrus

ND > D

267

0.002

-36

-20

6

4.1

L

Posterior insula

-38

-18

18

3.9

-46

-14

20

3.8

L

Secondary somato sensory cortex

Seed: Left AIns

D > ND

n.s.

ND > D

n.s.

Seed: Right AIns

D > ND

n.s.

ND > D

268

0.001

-10

22

54

4.5

L

Superior frontal gyrus

-12

34

46

3.8

188

0.010

52

18

-28

4.1

R

Temporal pole

42

20

-32

3.9

34

18

-28

3.2

161

0.021

-2

52

4

3.6

L

Anterior cingulate cortex

-4

50

12

3.6

8

52

-6

3.5

R

Medial prefrontal cortex

(B) Between-group difference in gray matter volume

cluster size (voxel)

clusterp_{FWE−corrected}

MNI coordinates

Z

Region

x

y

z

D > N

n.s.

ND > D

653

0.042

-50

0

38

4.5

L

Primary motor cortex

-59

-9

48

3.5

L

Primary somato sensory cortex

-59

2

21

3.4

(C) Association between the PPT-A score and seed-based connectivity

cluster size (voxel)

clusterp_{FWE−corrected}

MNI coordinates

Z

Region

x

y

z

Seed: Left SMN

Positive correlation

D

127

0.021

60

-30

40

3.9

R

Supramarginal gyrus

58

-32

32

3.6

Negative correlation

D

118

0.029

6

-50

-44

4.4

R

Cerebellum lobule 9

0

-52

-50

4.1

-8

-40

-46

3.9

L